Non-Ligand-Induced Dimerization is Sufficient to Initiate the Signalling and Endocytosis of EGF Receptor

The binding of epidermal growth factor (EGF) to EGF receptor (EGFR) stimulates cell mitogenesis and survival through various signalling cascades. EGF also stimulates rapid EGFR endocytosis and its eventual degradation in lysosomes. The immediate events induced by ligand binding include receptor dime...

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Bibliographic Details
Published in:Int J Mol Sci
Main Authors: Kourouniotis, George, Wang, Yi, Pennock, Steven, Chen, Xinmei, Wang, Zhixiang
Format: Artigo
Language:Inglês
Published: MDPI 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5000598/
https://ncbi.nlm.nih.gov/pubmed/27463710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms17081200
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