mTORC1 in the Paneth cell niche couples intestinal stem cell function to calorie intake

How adult tissue stem and niche cells respond to the nutritional state of an organism is not well understood. Here, we find that Paneth cells, a key constituent of the mammalian intestinal stem cell (ISC) niche, augment stem cell function in response to calorie restriction (CR). CR acts by reducing...

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Main Authors: Yilmaz, Ömer H., Katajisto, Pekka, Lamming, Dudley W., Gültekin, Yetis, Bauer-Rowe, Khristian E., Sengupta, Shomit, Birsoy, Kivanc, Dursun, Abdulmetin, Yilmaz, V. Onur, Selig, Martin, Nielson, G. Petur, Mino-Kenudson, Mari, Zukerberg, Lawrence, Bhan, Atul, Deshpande, Vikram, Sabatini, David M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2012
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3387287/
https://ncbi.nlm.nih.gov/pubmed/22722868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11163
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