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MTORC2 IN THE REGULATION OF MAMMALIAN LONGEVITY
Inhibition of the mTOR (mechanistic Target Of Rapamycin) signaling pathway by the FDA-approved drug rapamycin promotes lifespan in many species and delays age-related diseases in mice. While rapamycin was long assumed to be a specific inhibitor of mTOR complex 1 (mTORC1), which is acutely inhibited...
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| Publicado no: | Innov Aging |
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| Autor principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6228884/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/geroni/igy023.277 |
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