Single-molecule multiparameter fluorescence spectroscopy reveals directional MutS binding to mismatched bases in DNA

Mismatch repair (MMR) corrects replication errors such as mismatched bases and loops in DNA. The evolutionarily conserved dimeric MMR protein MutS recognizes mismatches by stacking a phenylalanine of one subunit against one base of the mismatched pair. In all crystal structures of G:T mismatch-bound...

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Main Authors: Cristóvão, Michele, Sisamakis, Evangelos, Hingorani, Manju M., Marx, Andreas D., Jung, Caroline P., Rothwell, Paul J., Seidel, Claus A. M., Friedhoff, Peter
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2012
Fag:
Genome Integrity, Repair and Replication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384296/
https://ncbi.nlm.nih.gov/pubmed/22367846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks138
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