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Multiparameter single-molecule fluorescence spectroscopy reveals heterogeneity of HIV-1 reverse transcriptase:primer/template complexes

By using single-molecule multiparameter fluorescence detection, fluorescence resonance energy transfer experiments, and newly developed data analysis methods, this study demonstrates directly the existence of three structurally distinct forms of reverse transcriptase (RT):nucleic acid complexes in s...

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Detalles Bibliográficos
Main Authors: Rothwell, P. J., Berger, S., Kensch, O., Felekyan, S., Antonik, M., Wöhrl, B. M., Restle, T., Goody, R. S., Seidel, C. A. M.
Formato: Artigo
Idioma:Inglês
Publicado: The National Academy of Sciences 2003
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC149888/
https://ncbi.nlm.nih.gov/pubmed/12578980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0434003100
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