Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease

Oncogenic ras alleles are among the most common mutations found in patients with acute myeloid leukemia (AML). Previously, the role of oncogenic ras in cancer was assessed in model systems overexpressing oncogenic ras from heterologous promoters. However, there is increasing evidence that subtle dif...

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Auteurs principaux: Chan, Iris T., Kutok, Jeffery L., Williams, Ifor R., Cohen, Sarah, Kelly, Lauren, Shigematsu, Hirokazu, Johnson, Leisa, Akashi, Koichi, Tuveson, David A., Jacks, Tyler, Gilliland, D. Gary
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2004
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC338267/
https://ncbi.nlm.nih.gov/pubmed/14966562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200420476
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