Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease

Oncogenic ras alleles are among the most common mutations found in patients with acute myeloid leukemia (AML). Previously, the role of oncogenic ras in cancer was assessed in model systems overexpressing oncogenic ras from heterologous promoters. However, there is increasing evidence that subtle dif...

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Main Authors: Chan, Iris T., Kutok, Jeffery L., Williams, Ifor R., Cohen, Sarah, Kelly, Lauren, Shigematsu, Hirokazu, Johnson, Leisa, Akashi, Koichi, Tuveson, David A., Jacks, Tyler, Gilliland, D. Gary
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2004
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC338267/
https://ncbi.nlm.nih.gov/pubmed/14966562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200420476
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