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Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease

Oncogenic ras alleles are among the most common mutations found in patients with acute myeloid leukemia (AML). Previously, the role of oncogenic ras in cancer was assessed in model systems overexpressing oncogenic ras from heterologous promoters. However, there is increasing evidence that subtle dif...

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Библиографические подробности
Главные авторы: Chan, Iris T., Kutok, Jeffery L., Williams, Ifor R., Cohen, Sarah, Kelly, Lauren, Shigematsu, Hirokazu, Johnson, Leisa, Akashi, Koichi, Tuveson, David A., Jacks, Tyler, Gilliland, D. Gary
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2004
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC338267/
https://ncbi.nlm.nih.gov/pubmed/14966562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200420476
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