Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype

Homozygous loss of function of Runx1 (Runt-related transcription factor 1 gene) during murine development results in an embryonic lethal phenotype characterized by a complete lack of definitive hematopoiesis. In light of recent reports of disparate requirements for hematopoietic transcription factor...

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Detalhes bibliográficos
Main Authors: Growney, Joseph D., Shigematsu, Hirokazu, Li, Zhe, Lee, Benjamin H., Adelsperger, Jennifer, Rowan, Rebecca, Curley, David P., Kutok, Jeffery L., Akashi, Koichi, Williams, Ifor R., Speck, Nancy A., Gilliland, D. Gary
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society of Hematology 2005
Assuntos:
Hematopoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895175/
https://ncbi.nlm.nih.gov/pubmed/15784726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2004-08-3280
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