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Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype

Homozygous loss of function of Runx1 (Runt-related transcription factor 1 gene) during murine development results in an embryonic lethal phenotype characterized by a complete lack of definitive hematopoiesis. In light of recent reports of disparate requirements for hematopoietic transcription factor...

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Autori principali: Growney, Joseph D., Shigematsu, Hirokazu, Li, Zhe, Lee, Benjamin H., Adelsperger, Jennifer, Rowan, Rebecca, Curley, David P., Kutok, Jeffery L., Akashi, Koichi, Williams, Ifor R., Speck, Nancy A., Gilliland, D. Gary
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society of Hematology 2005
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895175/
https://ncbi.nlm.nih.gov/pubmed/15784726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2004-08-3280
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