Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease

Oncogenic ras alleles are among the most common mutations found in patients with acute myeloid leukemia (AML). Previously, the role of oncogenic ras in cancer was assessed in model systems overexpressing oncogenic ras from heterologous promoters. However, there is increasing evidence that subtle dif...

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Detalhes bibliográficos
Main Authors: Chan, Iris T., Kutok, Jeffery L., Williams, Ifor R., Cohen, Sarah, Kelly, Lauren, Shigematsu, Hirokazu, Johnson, Leisa, Akashi, Koichi, Tuveson, David A., Jacks, Tyler, Gilliland, D. Gary
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2004
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC338267/
https://ncbi.nlm.nih.gov/pubmed/14966562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200420476
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