Oncogenic K-ras cooperates with PML-RARα to induce an acute promyelocytic leukemia-like disease

Most patients with acute promyelocytic leukemia (APL) express PML-RARα, the fusion product of t(15;17)(q22;q11.2). Transgenic mice expressing PML-RARα develop APL with long latency, low penetrance, and acquired cytogenetic abnormalities. Based on observations that 4% to 10% of APL patients harbor on...

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Detalhes bibliográficos
Main Authors: Chan, Iris T., Kutok, Jeffery L., Williams, Ifor R., Cohen, Sarah, Moore, Sandra, Shigematsu, Hirokazu, Ley, Timothy J., Akashi, Koichi, Le Beau, Michelle M., Gilliland, D. Gary
Formato: Artigo
Idioma:Inglês
Publicado em: © 2006 by The American Society of Hematology 2006
Assuntos:
Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895511/
https://ncbi.nlm.nih.gov/pubmed/16675706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-04-015040
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