PML/RARα and FLT3-ITD induce an APL-like disease in a mouse model

Acute promyelocytic leukemia (APL) cells invariably express aberrant fusion proteins involving the retinoic acid receptor α (RARα). The most common fusion partner is promyelocytic leukemia protein (PML), which is fused to RARα in the balanced reciprocal chromosomal translocation, t(15;17)(q22:q11)....

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Detalhes bibliográficos
Main Authors: Kelly, Louise M., Kutok, Jeffrey L., Williams, Ifor R., Boulton, Christina L., Amaral, Sonia M., Curley, David P., Ley, Timothy J., Gilliland, D. Gary
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2002
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC123059/
https://ncbi.nlm.nih.gov/pubmed/12060771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.122233699
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