PML-RARα and Dnmt3a1 Cooperate in vivo to Promote Acute Promyelocytic Leukemia

The PML-RARα oncogene is the central effector of acute promyelocytic leukemia (APL). PML-RARα physically interacts with epigenetic-modifying enzymes including DNA methyltransferases (Dnmt) to suppress critical downstream targets. Here, we show that increased expression of Dnmt3a1 cooperates with PML...

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Main Authors: Subramanyam, Deepa, Belair, Cassandra D., Barry-Holson, Keegan Q., Lin, Haijiang, Kogan, Scott C., Passegué, Emmanuelle, Blelloch, Robert
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3021794/
https://ncbi.nlm.nih.gov/pubmed/20861188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-4481
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