Llwytho...

Expression of oncogenic K-ras from its endogenous promoter leads to a partial block of erythroid differentiation and hyperactivation of cytokine-dependent signaling pathways

When overexpressed in primary erythroid progenitors, oncogenic Ras leads to the constitutive activation of its downstream signaling pathways, severe block of terminal erythroid differentiation, and cytokine-independent growth of primary erythroid progenitors. However, whether high-level expression o...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Zhang, Jing, Liu, Yangang, Beard, Caroline, Tuveson, David A., Jaenisch, Rudolf, Jacks, Tyler E., Lodish, Harvey F.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society of Hematology 2007
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1890843/
https://ncbi.nlm.nih.gov/pubmed/17317860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-09-047050
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