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Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis
Somatic activation of Ras occurs frequently in human cancers, including one-third of lung cancers. Activating Ras mutations also occur in the germline, leading to complex developmental syndromes. The precise mechanism by which Ras activation results in human disease is uncertain. Here we describe th...
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| Autori principali: | , , , , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Cold Spring Harbor Laboratory Press
2007
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1820943/ https://ncbi.nlm.nih.gov/pubmed/17369402 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1526207 |
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