Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis

Somatic activation of Ras occurs frequently in human cancers, including one-third of lung cancers. Activating Ras mutations also occur in the germline, leading to complex developmental syndromes. The precise mechanism by which Ras activation results in human disease is uncertain. Here we describe th...

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Autori principali: Shaw, Alice T., Meissner, Alexander, Dowdle, James A., Crowley, Denise, Magendantz, Margaret, Ouyang, Chensi, Parisi, Tiziana, Rajagopal, Jayaraj, Blank, Leah J., Bronson, Roderick T., Stone, James R., Tuveson, David A., Jaenisch, Rudolf, Jacks, Tyler
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2007
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1820943/
https://ncbi.nlm.nih.gov/pubmed/17369402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1526207
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