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Structures of Asymmetric Complexes of Human Neuron Specific Enolase with Resolved Substrate and Product and an Analogous Complex with Two Inhibitors Indicate Subunits Interaction and Inhibitors Cooperativity

In the presence of magnesium, enolase catalyzes the dehydration of 2-phospho-D-glycerate (PGA) to phosphoenolpyruvate (PEP) in glycolysis and the reverse reaction in gluconeogensis at comparable rates. The structure of human neuron specific enolase (hNSE) crystals soaked in PGA showed that the enzym...

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Bibliografske podrobnosti
Main Authors: Qin, Jie, Chai, Geqing, Brewer, John M., Lovelace, Leslie L., Lebioda, Lukasz
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3371154/
https://ncbi.nlm.nih.gov/pubmed/22437160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jinorgbio.2012.02.011
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