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Structures of Asymmetric Complexes of Human Neuron Specific Enolase with Resolved Substrate and Product and an Analogous Complex with Two Inhibitors Indicate Subunits Interaction and Inhibitors Cooperativity

In the presence of magnesium, enolase catalyzes the dehydration of 2-phospho-D-glycerate (PGA) to phosphoenolpyruvate (PEP) in glycolysis and the reverse reaction in gluconeogensis at comparable rates. The structure of human neuron specific enolase (hNSE) crystals soaked in PGA showed that the enzym...

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Main Authors: Qin, Jie, Chai, Geqing, Brewer, John M., Lovelace, Leslie L., Lebioda, Lukasz
格式: Artigo
語言:Inglês
出版: 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3371154/
https://ncbi.nlm.nih.gov/pubmed/22437160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jinorgbio.2012.02.011
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