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Crystal Structure of the MACPF Domain of Human Complement Protein C8α in Complex with the C8γ Subunit

Human C8 is one of five complement components (C5b, C6, C7, C8 and C9) that assemble on bacterial membranes to form a pore-like structure referred to as the "membrane attack complex" (MAC). C8 contains three genetically distinct subunits (C8α, C8β, Cγ.) arranged as a disulfide-linked C8α-γ...

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Detalhes bibliográficos
Main Authors: Slade, Daniel J., Lovelace, Leslie L., Chruszcz, Maksymilian, Minor, Wladek, Lebioda, Lukasz, Sodetz, James M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2443722/
https://ncbi.nlm.nih.gov/pubmed/18440555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.03.061
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