Crystal Structure of the MACPF Domain of Human Complement Protein C8α in Complex with the C8γ Subunit

Human C8 is one of five complement components (C5b, C6, C7, C8 and C9) that assemble on bacterial membranes to form a pore-like structure referred to as the "membrane attack complex" (MAC). C8 contains three genetically distinct subunits (C8α, C8β, Cγ.) arranged as a disulfide-linked C8α-γ...

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Bibliographic Details
Main Authors: Slade, Daniel J., Lovelace, Leslie L., Chruszcz, Maksymilian, Minor, Wladek, Lebioda, Lukasz, Sodetz, James M.
Format: Artigo
Language:Inglês
Published: 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2443722/
https://ncbi.nlm.nih.gov/pubmed/18440555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.03.061
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