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Structure of Human C8 Protein Provides Mechanistic Insight into Membrane Pore Formation by Complement
C8 is one of five complement proteins that assemble on bacterial membranes to form the lethal pore-like “membrane attack complex” (MAC) of complement. The MAC consists of one C5b, C6, C7, and C8 and 12–18 molecules of C9. C8 is composed of three genetically distinct subunits, C8α, C8β, and C8γ. The...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3093833/ https://ncbi.nlm.nih.gov/pubmed/21454577 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.219766 |
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