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Inhibition of factor XI activation attenuates inflammation and coagulopathy while improving the survival of mouse polymicrobial sepsis

Severe bacterial sepsis often leads to a systemic procoagulant and proinflammatory condition that can manifest as disseminated intravascular coagulation, septic shock, and multiple organ failure. Because activation of the contact proteases factor XII (FXII), prekallikrein, and factor XI (FXI) can tr...

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書誌詳細
主要な著者: Tucker, Erik I., Verbout, Norah G., Leung, Philberta Y., Hurst, Sawan, McCarty, Owen J. T., Gailani, David, Gruber, András
フォーマット: Artigo
言語:Inglês
出版事項: American Society of Hematology 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3367876/
https://ncbi.nlm.nih.gov/pubmed/22442348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-10-386185
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