Inhibition of factor XI activation attenuates inflammation and coagulopathy while improving the survival of mouse polymicrobial sepsis

Severe bacterial sepsis often leads to a systemic procoagulant and proinflammatory condition that can manifest as disseminated intravascular coagulation, septic shock, and multiple organ failure. Because activation of the contact proteases factor XII (FXII), prekallikrein, and factor XI (FXI) can tr...

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Bibliografiske detaljer
Main Authors: Tucker, Erik I., Verbout, Norah G., Leung, Philberta Y., Hurst, Sawan, McCarty, Owen J. T., Gailani, David, Gruber, András
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2012
Fag:
Thrombosis and Hemostasis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3367876/
https://ncbi.nlm.nih.gov/pubmed/22442348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-10-386185
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