Inhibition of factor XI activation attenuates inflammation and coagulopathy while improving the survival of mouse polymicrobial sepsis

Severe bacterial sepsis often leads to a systemic procoagulant and proinflammatory condition that can manifest as disseminated intravascular coagulation, septic shock, and multiple organ failure. Because activation of the contact proteases factor XII (FXII), prekallikrein, and factor XI (FXI) can tr...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Tucker, Erik I., Verbout, Norah G., Leung, Philberta Y., Hurst, Sawan, McCarty, Owen J. T., Gailani, David, Gruber, András
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society of Hematology 2012
Pynciau:
Thrombosis and Hemostasis
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3367876/
https://ncbi.nlm.nih.gov/pubmed/22442348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-10-386185
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