Factor XI Deficiency Alters the Cytokine Response and Activation of Contact Proteases during Polymicrobial Sepsis in Mice

Sepsis, a systemic inflammatory response to infection, is often accompanied by abnormalities of blood coagulation. Prior work with a mouse model of sepsis induced by cecal ligation and puncture (CLP) suggested that the protease factor XIa contributed to disseminated intravascular coagulation (DIC) a...

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Udgivet i:PLoS One
Main Authors: Bane, Charles E., Ivanov, Ivan, Matafonov, Anton, Boyd, Kelli L., Cheng, Qiufang, Sherwood, Edward R., Tucker, Erik I., Smiley, Stephen T., McCarty, Owen J. T., Gruber, Andras, Gailani, David
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4821616/
https://ncbi.nlm.nih.gov/pubmed/27046148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0152968
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