Nucleic Acids as Cofactors for Factor XI and Prekallikrein Activation: Different roles for high molecular weight kininogen

The plasma zymogens factor XI (fXI) and prekallikrein (PK) are activated by factor XIIa (fXIIa) during contact activation. Polyanions such as DNA and RNA may contribute to thrombosis and inflammation partly by enhancing PK and fXI activation. We examined PK and fXI activation in the presence of nucl...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Thromb Haemost
Prif Awduron: Ivanov, Ivan, Shakhawat, Ruhama, Sun, Mao-fu, Dickeson, S. Kent, Puy, Cristina, McCarty, Owen J.T., Gruber, Andras, Matafonov, Anton, Gailani, David
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5696789/
https://ncbi.nlm.nih.gov/pubmed/28124063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1160/TH16-09-0691
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg