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Activated factor XI increases the procoagulant activity of the extrinsic pathway by inactivating tissue factor pathway inhibitor

Activation of coagulation factor XI (FXI) may play a role in hemostasis. The primary substrate of activated FXI (FXIa) is FIX, leading to FX activation (FXa) and thrombin generation. However, recent studies suggest the hemostatic role of FXI may not be restricted to the activation of FIX. We explore...

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書誌詳細
出版年:Blood
主要な著者: Puy, Cristina, Tucker, Erik I., Matafonov, Anton, Cheng, Qiufang, Zientek, Keith D., Gailani, Dave, Gruber, András, McCarty, Owen J. T.
フォーマット: Artigo
言語:Inglês
出版事項: American Society of Hematology 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4342360/
https://ncbi.nlm.nih.gov/pubmed/25587039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-10-604587
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