Activated factor XI increases the procoagulant activity of the extrinsic pathway by inactivating tissue factor pathway inhibitor

Activation of coagulation factor XI (FXI) may play a role in hemostasis. The primary substrate of activated FXI (FXIa) is FIX, leading to FX activation (FXa) and thrombin generation. However, recent studies suggest the hemostatic role of FXI may not be restricted to the activation of FIX. We explore...

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Publicado en:Blood
Autores principales: Puy, Cristina, Tucker, Erik I., Matafonov, Anton, Cheng, Qiufang, Zientek, Keith D., Gailani, Dave, Gruber, András, McCarty, Owen J. T.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2015
Materias:
Thrombosis and Hemostasis
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4342360/
https://ncbi.nlm.nih.gov/pubmed/25587039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-10-604587
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