Crosstalk between the complement pathway and the contact activation system of coagulation: activated factor XI neutralizes complement factor H.

Complement factor H (CFH) is the major inhibitor of the alternative pathway of the complement system and is structurally related to beta2-glycoprotein I, which itself is known to bind to ligands including coagulation factor XI (FXI). We observed reduced complement activation when FXI activation was...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Puy, Cristina, Pang, Jiaqing, Reitsma, Stéphanie E., Lorentz, Christina U., Tucker, Erik I., Gailani, David, Gruber, András, Lupu, Florea, McCarty, Owen J.T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8030746/
https://ncbi.nlm.nih.gov/pubmed/33811105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.2000398
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