Factor XII promotes blood coagulation independent of factor XI in the presence of long chain polyphosphate

BACKGROUND: Inorganic polyphosphates (polyP), which are secreted by activated platelets (short chain polyP) and accumulate in some bacteria (long chain polyP), support the contact activation of factor XII (FXII), and accelerate the activation of factor XI (FXI). OBJECTIVES: The aim of the present st...

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Main Authors: Puy, Cristina, Tucker, Erik I., Wong, Zoë C., Gailani, David, Smith, Stephanie A., Choi, Sharon H., Morrissey, James H., Gruber, András, McCarty, Owen J. T.
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3714337/
https://ncbi.nlm.nih.gov/pubmed/23659638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.12295
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