Removal of the C-Terminal Domains of ADAMTS13 by Activated Coagulation Factor XI induces Platelet Adhesion on Endothelial Cells under Flow Conditions

Platelet recruitment to sites of vascular injury is mediated by von Willebrand factor (VWF). The shear-induced unraveling of ultra-large VWF multimers causes the formation of a “stringlike” conformation, which rapidly recruits platelets from the bloodstream. A disintegrin and metalloproteinase with...

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Vydáno v:Front Med (Lausanne)
Hlavní autoři: Garland, Kathleen S., Reitsma, Stéphanie E., Shirai, Toshiaki, Zilberman-Rudenko, Jevgenia, Tucker, Erik I., Gailani, David, Gruber, András, McCarty, Owen J. T., Puy, Cristina
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2017
Témata:
Medicine
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5742325/
https://ncbi.nlm.nih.gov/pubmed/29326937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmed.2017.00232
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