Removal of the C-Terminal Domains of ADAMTS13 by Activated Coagulation Factor XI induces Platelet Adhesion on Endothelial Cells under Flow Conditions

Platelet recruitment to sites of vascular injury is mediated by von Willebrand factor (VWF). The shear-induced unraveling of ultra-large VWF multimers causes the formation of a “stringlike” conformation, which rapidly recruits platelets from the bloodstream. A disintegrin and metalloproteinase with...

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Detalhes bibliográficos
Publicado no:Front Med (Lausanne)
Main Authors: Garland, Kathleen S., Reitsma, Stéphanie E., Shirai, Toshiaki, Zilberman-Rudenko, Jevgenia, Tucker, Erik I., Gailani, David, Gruber, András, McCarty, Owen J. T., Puy, Cristina
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5742325/
https://ncbi.nlm.nih.gov/pubmed/29326937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmed.2017.00232
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