Factor XI contributes to thrombin generation in the absence of factor XII

During surface-initiated blood coagulation in vitro, activated factor XII (fXIIa) converts factor XI (fXI) to fXIa. Whereas fXI deficiency is associated with a hemorrhagic disorder, factor XII deficiency is not, suggesting that fXI can be activated by other mechanisms in vivo. Thrombin activates fXI...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Kravtsov, Dmitri V., Matafonov, Anton, Tucker, Erik I., Sun, Mao-fu, Walsh, Peter N., Gruber, Andras, Gailani, David
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society of Hematology 2009
Pynciau:
Thrombosis and Hemostasis
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2714215/
https://ncbi.nlm.nih.gov/pubmed/19351955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-02-203604
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg