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Factor XI contributes to thrombin generation in the absence of factor XII
During surface-initiated blood coagulation in vitro, activated factor XII (fXIIa) converts factor XI (fXI) to fXIa. Whereas fXI deficiency is associated with a hemorrhagic disorder, factor XII deficiency is not, suggesting that fXI can be activated by other mechanisms in vivo. Thrombin activates fXI...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society of Hematology
2009
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2714215/ https://ncbi.nlm.nih.gov/pubmed/19351955 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-02-203604 |
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