Factor XI contributes to thrombin generation in the absence of factor XII

During surface-initiated blood coagulation in vitro, activated factor XII (fXIIa) converts factor XI (fXI) to fXIa. Whereas fXI deficiency is associated with a hemorrhagic disorder, factor XII deficiency is not, suggesting that fXI can be activated by other mechanisms in vivo. Thrombin activates fXI...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Kravtsov, Dmitri V., Matafonov, Anton, Tucker, Erik I., Sun, Mao-fu, Walsh, Peter N., Gruber, Andras, Gailani, David
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society of Hematology 2009
Gaiak:
Thrombosis and Hemostasis
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2714215/
https://ncbi.nlm.nih.gov/pubmed/19351955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-02-203604
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