Factor XII inhibition reduces thrombus formation in a primate thrombosis model

The plasma zymogens factor XII (fXII) and factor XI (fXI) contribute to thrombosis in a variety of mouse models. These proteins serve a limited role in hemostasis, suggesting that antithrombotic therapies targeting them may be associated with low bleeding risks. Although there is substantial epidemi...

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Main Authors: Matafonov, Anton, Leung, Philberta Y., Gailani, Adam E., Grach, Stephanie L., Puy, Cristina, Cheng, Qiufang, Sun, Mao-fu, McCarty, Owen J. T., Tucker, Erik I., Kataoka, Hiroaki, Renné, Thomas, Morrissey, James H., Gruber, Andras, Gailani, David
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2014
Fag:
Thrombosis and Hemostasis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3954054/
https://ncbi.nlm.nih.gov/pubmed/24408325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-04-499111
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