Antibody inhibition of contact factor XII reduces platelet deposition in a model of extracorporeal membrane oxygenator perfusion in nonhuman primates

BACKGROUND: The contact factor XII (FXII) activates upon contact with a variety of charged surfaces. Activated FXII (FXIIa) activates factor XI, which activates factor IX, resulting in thrombin generation, platelet activation, and fibrin formation. In both in vitro and in vivo rabbit models, compone...

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Detalhes bibliográficos
Publicado no:Res Pract Thromb Haemost
Main Authors: Wallisch, Michael, Lorentz, Christina U., Lakshmanan, Hari H. S., Johnson, Jennifer, Carris, Marschelle R., Puy, Cristina, Gailani, David, Hinds, Monica T., McCarty, Owen J. T., Gruber, András, Tucker, Erik I.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Original Articles: Thrombosis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7040549/
https://ncbi.nlm.nih.gov/pubmed/32110750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/rth2.12309
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