Factor XII plays a pathogenic role in organ failure and death in baboons challenged with Staphylococcus aureus

Activation of coagulation factor (F) XI promotes multiorgan failure in rodent models of sepsis and in a baboon model of lethal systemic inflammation induced by infusion of heat-inactivated Staphylococcus aureus. Here we used the anticoagulant FXII-neutralizing antibody 5C12 to verify the mechanistic...

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Publicado en:Blood
Autores principales: Silasi, Robert, Keshari, Ravi S., Regmi, Girija, Lupu, Cristina, Georgescu, Constantin, Simmons, Joe H., Wallisch, Michael, Kohs, Tia C. L., Shatzel, Joseph J., Olson, Sven R., Lorentz, Christina U., Puy, Cristina, Tucker, Erik I., Gailani, David, Strickland, Sidney, Gruber, András, McCarty, Owen J. T., Lupu, Florea
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2021
Materias:
Thrombosis and Hemostasis
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8288658/
https://ncbi.nlm.nih.gov/pubmed/33598692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020009345
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