Factor XII plays a pathogenic role in organ failure and death in baboons challenged with Staphylococcus aureus

Activation of coagulation factor (F) XI promotes multiorgan failure in rodent models of sepsis and in a baboon model of lethal systemic inflammation induced by infusion of heat-inactivated Staphylococcus aureus. Here we used the anticoagulant FXII-neutralizing antibody 5C12 to verify the mechanistic...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Silasi, Robert, Keshari, Ravi S., Regmi, Girija, Lupu, Cristina, Georgescu, Constantin, Simmons, Joe H., Wallisch, Michael, Kohs, Tia C. L., Shatzel, Joseph J., Olson, Sven R., Lorentz, Christina U., Puy, Cristina, Tucker, Erik I., Gailani, David, Strickland, Sidney, Gruber, András, McCarty, Owen J. T., Lupu, Florea
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2021
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8288658/
https://ncbi.nlm.nih.gov/pubmed/33598692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020009345
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