Fondaparinux pentasaccharide reduces sepsis coagulopathy and promotes survival in the baboon model of E. coli sepsis

BACKGROUND: Sepsis triggers dysfunction of coagulation and fibrinolytic systems leading to disseminated intravascular coagulation (DIC) that contributes to organ failure and death. Fondaparinux (FPX) is a synthetic pentasaccharide that binds to antithrombin (AT) and selectively inhibits factor (F) X...

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Vydáno v:J Thromb Haemost
Hlavní autoři: Keshari, Ravi S., Silasi, Robert, Popescu, Narcis I., Georgescu, Constantin, Chaaban, Hala, Lupu, Cristina, McCarty, Owen J. T., Esmon, Charles T., Lupu, Florea
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6940562/
https://ncbi.nlm.nih.gov/pubmed/31549765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.14642
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