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Inhibition of complement C5 protects against organ failure and reduces mortality in a baboon model of Escherichia coli sepsis

Bacterial sepsis triggers robust activation of the complement system with subsequent generation of anaphylatoxins (C3a, C5a) and the terminal complement complex (TCC) that together contribute to organ failure and death. Here we tested the effect of RA101295, a 2-kDa macrocyclic peptide inhibitor of...

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書誌詳細
出版年:Proc Natl Acad Sci U S A
主要な著者: Keshari, Ravi Shankar, Silasi, Robert, Popescu, Narcis Ioan, Patel, Maulin Mukeshchandra, Chaaban, Hala, Lupu, Cristina, Coggeshall, K. Mark, Mollnes, Tom Eirik, DeMarco, Steven J., Lupu, Florea
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5547645/
https://ncbi.nlm.nih.gov/pubmed/28720697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1706818114
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