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Inhibition of complement C5 protects against organ failure and reduces mortality in a baboon model of Escherichia coli sepsis
Bacterial sepsis triggers robust activation of the complement system with subsequent generation of anaphylatoxins (C3a, C5a) and the terminal complement complex (TCC) that together contribute to organ failure and death. Here we tested the effect of RA101295, a 2-kDa macrocyclic peptide inhibitor of...
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| 出版年: | Proc Natl Acad Sci U S A |
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| 主要な著者: | , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5547645/ https://ncbi.nlm.nih.gov/pubmed/28720697 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1706818114 |
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