Inhibition of complement C5 protects against organ failure and reduces mortality in a baboon model of Escherichia coli sepsis

Bacterial sepsis triggers robust activation of the complement system with subsequent generation of anaphylatoxins (C3a, C5a) and the terminal complement complex (TCC) that together contribute to organ failure and death. Here we tested the effect of RA101295, a 2-kDa macrocyclic peptide inhibitor of...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Keshari, Ravi Shankar, Silasi, Robert, Popescu, Narcis Ioan, Patel, Maulin Mukeshchandra, Chaaban, Hala, Lupu, Cristina, Coggeshall, K. Mark, Mollnes, Tom Eirik, DeMarco, Steven J., Lupu, Florea
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2017
Sujets:
PNAS Plus
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5547645/
https://ncbi.nlm.nih.gov/pubmed/28720697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1706818114
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