Inhibition of complement C5 protects against organ failure and reduces mortality in a baboon model of Escherichia coli sepsis

Bacterial sepsis triggers robust activation of the complement system with subsequent generation of anaphylatoxins (C3a, C5a) and the terminal complement complex (TCC) that together contribute to organ failure and death. Here we tested the effect of RA101295, a 2-kDa macrocyclic peptide inhibitor of...

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發表在:Proc Natl Acad Sci U S A
Main Authors: Keshari, Ravi Shankar, Silasi, Robert, Popescu, Narcis Ioan, Patel, Maulin Mukeshchandra, Chaaban, Hala, Lupu, Cristina, Coggeshall, K. Mark, Mollnes, Tom Eirik, DeMarco, Steven J., Lupu, Florea
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2017
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PNAS Plus
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5547645/
https://ncbi.nlm.nih.gov/pubmed/28720697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1706818114
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