Factor XII plays a pathogenic role in organ failure and death in baboons challenged with Staphylococcus aureus

Activation of coagulation factor (F) XI promotes multiorgan failure in rodent models of sepsis and in a baboon model of lethal systemic inflammation induced by infusion of heat-inactivated Staphylococcus aureus. Here we used the anticoagulant FXII-neutralizing antibody 5C12 to verify the mechanistic...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Blood
Egile Nagusiak: Silasi, Robert, Keshari, Ravi S., Regmi, Girija, Lupu, Cristina, Georgescu, Constantin, Simmons, Joe H., Wallisch, Michael, Kohs, Tia C. L., Shatzel, Joseph J., Olson, Sven R., Lorentz, Christina U., Puy, Cristina, Tucker, Erik I., Gailani, David, Strickland, Sidney, Gruber, András, McCarty, Owen J. T., Lupu, Florea
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society of Hematology 2021
Gaiak:
Thrombosis and Hemostasis
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8288658/
https://ncbi.nlm.nih.gov/pubmed/33598692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020009345
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