Antibody inhibition of contact factor XII reduces platelet deposition in a model of extracorporeal membrane oxygenator perfusion in nonhuman primates

BACKGROUND: The contact factor XII (FXII) activates upon contact with a variety of charged surfaces. Activated FXII (FXIIa) activates factor XI, which activates factor IX, resulting in thrombin generation, platelet activation, and fibrin formation. In both in vitro and in vivo rabbit models, compone...

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Bibliographische Detailangaben
Veröffentlicht in:Res Pract Thromb Haemost
Hauptverfasser: Wallisch, Michael, Lorentz, Christina U., Lakshmanan, Hari H. S., Johnson, Jennifer, Carris, Marschelle R., Puy, Cristina, Gailani, David, Hinds, Monica T., McCarty, Owen J. T., Gruber, András, Tucker, Erik I.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2020
Schlagworte:
Original Articles: Thrombosis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7040549/
https://ncbi.nlm.nih.gov/pubmed/32110750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/rth2.12309
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