Prevention of vascular graft occlusion and thrombus-associated thrombin generation by inhibition of factor XI

The protease thrombin is required for normal hemostasis and pathologic thrombogenesis. Since the mechanism of coagulation factor XI (FXI)–dependent thrombus growth remains unclear, we investigated the contribution of FXI to thrombus formation in a primate thrombosis model. Pretreatment of baboons wi...

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Detalhes bibliográficos
Main Authors: Tucker, Erik I., Marzec, Ulla M., White, Tara C., Hurst, Sawan, Rugonyi, Sandra, McCarty, Owen J. T., Gailani, David, Gruber, András, Hanson, Stephen R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2009
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2630279/
https://ncbi.nlm.nih.gov/pubmed/18945968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-06-163675
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