A role for factor XIIa–mediated factor XI activation in thrombus formation in vivo

Mice lacking factor XII (fXII) or factor XI (fXI) are resistant to experimentally–induced thrombosis, suggesting fXIIa activation of fXI contributes to thrombus formation in vivo. It is not clear whether this reaction has relevance for thrombosis in pri mates. In 2 carotid artery injury models (FeCl...

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Bibliographische Detailangaben
Hauptverfasser: Cheng, Qiufang, Tucker, Erik I., Pine, Meghann S., Sisler, India, Matafonov, Anton, Sun, Mao-fu, White-Adams, Tara C., Smith, Stephanie A., Hanson, Stephen R., McCarty, Owen J. T., Renné, Thomas, Gruber, András, Gailani, David
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2010
Schlagworte:
Thrombosis and Hemostasis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2981546/
https://ncbi.nlm.nih.gov/pubmed/20634381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-02-270918
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