A role for factor XIIa–mediated factor XI activation in thrombus formation in vivo

Mice lacking factor XII (fXII) or factor XI (fXI) are resistant to experimentally–induced thrombosis, suggesting fXIIa activation of fXI contributes to thrombus formation in vivo. It is not clear whether this reaction has relevance for thrombosis in pri mates. In 2 carotid artery injury models (FeCl...

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Detalhes bibliográficos
Main Authors: Cheng, Qiufang, Tucker, Erik I., Pine, Meghann S., Sisler, India, Matafonov, Anton, Sun, Mao-fu, White-Adams, Tara C., Smith, Stephanie A., Hanson, Stephen R., McCarty, Owen J. T., Renné, Thomas, Gruber, András, Gailani, David
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2981546/
https://ncbi.nlm.nih.gov/pubmed/20634381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-02-270918
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