A role for factor XIIa–mediated factor XI activation in thrombus formation in vivo

Mice lacking factor XII (fXII) or factor XI (fXI) are resistant to experimentally–induced thrombosis, suggesting fXIIa activation of fXI contributes to thrombus formation in vivo. It is not clear whether this reaction has relevance for thrombosis in pri mates. In 2 carotid artery injury models (FeCl...

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Main Authors: Cheng, Qiufang, Tucker, Erik I., Pine, Meghann S., Sisler, India, Matafonov, Anton, Sun, Mao-fu, White-Adams, Tara C., Smith, Stephanie A., Hanson, Stephen R., McCarty, Owen J. T., Renné, Thomas, Gruber, András, Gailani, David
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2010
Teme:
Thrombosis and Hemostasis
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2981546/
https://ncbi.nlm.nih.gov/pubmed/20634381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-02-270918
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