Altered immunoglobulin hypermutation pattern and frequency in complementary mouse models of DNA polymerase ζ activity

To test the hypothesis that DNA polymerase ζ participates in immunoglobulin hypermutation, we generated two mouse models of Pol ζ function: a B-cell specific conditional knock-out and a knock-in strain with a Pol ζ mutagenesis-enhancing mutation. Pol ζ-deficient B-cells had a reduction in mutation f...

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Main Authors: Daly, Janssen, Bebenek, Katarzyna, Watt, Danielle L., Richter, Kathleen, Jiang, Chuancang, Zhao, Ming-Lang, Ray, Madhumita, McGregor, W. Glenn, Kunkel, Thomas A., Diaz, Marilyn
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3358437/
https://ncbi.nlm.nih.gov/pubmed/22547703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1102629
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