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Altered Pattern of Immunoglobulin Hypermutation in Mice Deficient in Slip-GC Protein
We recently identified a novel germinal center GTPase, SLIP-GC, that localizes to replication factories in B cells and that, when reduced, induces DNA breaks in lymphoma B cell lines in an activation-induced deaminase (AID)-dependent manner. Herein, we generated mice deficient in SLIP-GC and examine...
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| Autors principals: | , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3442519/ https://ncbi.nlm.nih.gov/pubmed/22833677 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.340661 |
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