Altered Pattern of Immunoglobulin Hypermutation in Mice Deficient in Slip-GC Protein

We recently identified a novel germinal center GTPase, SLIP-GC, that localizes to replication factories in B cells and that, when reduced, induces DNA breaks in lymphoma B cell lines in an activation-induced deaminase (AID)-dependent manner. Herein, we generated mice deficient in SLIP-GC and examine...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Richter, Kathleen, Burch, Lauranell, Chao, Frank, Henke, David, Jiang, Chuancang, Daly, Janssen, Zhao, Ming-Lang, Kissling, Grace, Diaz, Marilyn
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2012
Sujets:
Immunology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3442519/
https://ncbi.nlm.nih.gov/pubmed/22833677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.340661
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