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Altered immunoglobulin hypermutation pattern and frequency in complementary mouse models of DNA polymerase ζ activity
To test the hypothesis that DNA polymerase ζ participates in immunoglobulin hypermutation, we generated two mouse models of Pol ζ function: a B-cell specific conditional knock-out and a knock-in strain with a Pol ζ mutagenesis-enhancing mutation. Pol ζ-deficient B-cells had a reduction in mutation f...
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| Hauptverfasser: | , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3358437/ https://ncbi.nlm.nih.gov/pubmed/22547703 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1102629 |
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