An Optically Pure Apogossypolone Derivative as Potent Pan-Active Inhibitor of Anti-Apoptotic Bcl-2 Family Proteins

Our focus in the past several years has been on the identification of novel and effective pan-Bcl-2 antagonists. We have recently reported a series of Apogossypolone (ApoG2) derivatives, resulting in the chiral compound (±) BI97D6. We report here the synthesis and evaluation on its optically pure (−...

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Détails bibliographiques
Auteurs principaux: Wei, Jun, Stebbins, John L., Kitada, Shinichi, Dash, Rupesh, Zhai, Dayong, Placzek, William J., Wu, Bainan, Rega, Michele F., Zhang, Ziming, Barile, Elisa, Yang, Li, Dahl, Russell, Fisher, Paul B., Reed, John C., Pellecchia, Maurizio
Format: Artigo
Langue:Inglês
Publié: Frontiers Research Foundation 2011
Sujets:
Oncology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3356046/
https://ncbi.nlm.nih.gov/pubmed/22655238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2011.00028
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