An Optically Pure Apogossypolone Derivative as Potent Pan-Active Inhibitor of Anti-Apoptotic Bcl-2 Family Proteins

Our focus in the past several years has been on the identification of novel and effective pan-Bcl-2 antagonists. We have recently reported a series of Apogossypolone (ApoG2) derivatives, resulting in the chiral compound (±) BI97D6. We report here the synthesis and evaluation on its optically pure (−...

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Main Authors: Wei, Jun, Stebbins, John L., Kitada, Shinichi, Dash, Rupesh, Zhai, Dayong, Placzek, William J., Wu, Bainan, Rega, Michele F., Zhang, Ziming, Barile, Elisa, Yang, Li, Dahl, Russell, Fisher, Paul B., Reed, John C., Pellecchia, Maurizio
格式: Artigo
語言:Inglês
出版: Frontiers Research Foundation 2011
主題:
Oncology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3356046/
https://ncbi.nlm.nih.gov/pubmed/22655238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2011.00028
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