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p85β regulatory subunit of class I(A) PI3 kinase negatively regulates mast cell growth, maturation, and leukemogenesis
We show that loss of p85α inhibits the growth and maturation of mast cells, whereas loss of p85β enhances this process. Whereas restoring the expression of p85α in P85α(−/−) cells restores these functions, overexpression of p85β has the opposite effect. Consistently, overexpression of p85β in WT mas...
Gorde:
| Egile Nagusiak: | , , , , , , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
American Society of Hematology
2012
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3350362/ https://ncbi.nlm.nih.gov/pubmed/22378847 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-05-355602 |
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