p85β regulatory subunit of class I(A) PI3 kinase negatively regulates mast cell growth, maturation, and leukemogenesis

We show that loss of p85α inhibits the growth and maturation of mast cells, whereas loss of p85β enhances this process. Whereas restoring the expression of p85α in P85α(−/−) cells restores these functions, overexpression of p85β has the opposite effect. Consistently, overexpression of p85β in WT mas...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Hoofdauteurs: Krishnan, Subha, Mali, Raghuveer Singh, Ramdas, Baskar, Sims, Emily, Ma, Peilin, Ghosh, Joydeep, Munugalavadla, Veerendra, Hanneman, Philip, Beane, Joal D., Kapur, Reuben
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2012
Onderwerpen:
Hematopoiesis and Stem Cells
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3350362/
https://ncbi.nlm.nih.gov/pubmed/22378847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-05-355602
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items