The PI3K pathway drives the maturation of mast cells via microphthalmia transcription factor

Mast cell maturation is poorly understood. We show that enhanced PI3K activation results in accelerated maturation of mast cells by inducing the expression of microphthalmia transcription factor (Mitf). Conversely, loss of PI3K activation reduces the maturation of mast cells by inhibiting the activa...

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Autors principals: Ma, Peilin, Mali, Raghuveer Singh, Munugalavadla, Veerendra, Krishnan, Subha, Ramdas, Baskar, Sims, Emily, Martin, Holly, Ghosh, Joydeep, Li, Shuo, Chan, Rebecca J., Krystal, Gerald, Craig, Andrew W., Takemoto, Clifford, Kapur, Reuben
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2011
Matèries:
Plenary Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3186328/
https://ncbi.nlm.nih.gov/pubmed/21791431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-04-351809
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