p85β regulatory subunit of class I(A) PI3 kinase negatively regulates mast cell growth, maturation, and leukemogenesis

We show that loss of p85α inhibits the growth and maturation of mast cells, whereas loss of p85β enhances this process. Whereas restoring the expression of p85α in P85α(−/−) cells restores these functions, overexpression of p85β has the opposite effect. Consistently, overexpression of p85β in WT mas...

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Hlavní autoři: Krishnan, Subha, Mali, Raghuveer Singh, Ramdas, Baskar, Sims, Emily, Ma, Peilin, Ghosh, Joydeep, Munugalavadla, Veerendra, Hanneman, Philip, Beane, Joal D., Kapur, Reuben
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2012
Témata:
Hematopoiesis and Stem Cells
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3350362/
https://ncbi.nlm.nih.gov/pubmed/22378847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-05-355602
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