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MicroRNA Targeting of Neurotropic Flavivirus: Effective Control of Virus Escape and Reversion to Neurovirulent Phenotype

Neurotropic flaviviruses can efficiently replicate in the developing and mature central nervous systems (CNS) of mice causing lethal encephalitis. Insertion of a single copy of a target for brain-expressed microRNAs (miRNAs) in the 3′ noncoding region (3′NCR) of the flavivirus genome (chimeric tick-...

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Xehetasun bibliografikoak
Egile Nagusiak: Heiss, Brian L., Maximova, Olga A., Thach, Dzung C., Speicher, James M., Pletnev, Alexander G.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2012
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3347253/
https://ncbi.nlm.nih.gov/pubmed/22419812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.07125-11
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